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Immune Health & Longevity
Treatment built around you, and watched closely
Chronic inflammation is linked to many of the symptoms people struggle with most: fatigue, pain, brain fog, low mood, and anxiety. We look for what’s driving inflammation, including sleep, diet, stress, gut health, and autoimmune activity, and address it directly. For some patients, that plan includes medications like low dose naltrexone or low-dose rapamycin.
The goal isn’t just more years. It’s more good years.
Low dose naltrexone (LDN)
At low doses, typically 1.5 to 4.5 mg daily, naltrexone works very differently than at the standard dose. Instead of blocking opioid receptors long-term, it appears to calm the immune system and boost the body’s own endorphins.
LDN has drawn interest for:
• Immune regulation: calming an overactive immune system in conditions such as multiple sclerosis and lupus
• Chronic pain: including fibromyalgia
• Mood: some patients report improved mood and less anxiety
• Digestive inflammation: symptoms of Crohn’s disease and irritable bowel syndrome
• Nerve protection: an active area of research in neurodegenerative disease
How it’s prescribed. LDN isn’t sold commercially at these doses, so it’s made by a compounding pharmacy. That also means the dose and form, such as capsules, liquid, or cream, can be tailored to you.
What to expect. We start with a low dose and increase gradually. Many patients take it at bedtime. It can take up to 8 weeks to feel the full benefit, and we’ll track your symptoms and any side effects together. LDN can’t be used with opioid medications, and alcohol should be limited.
Rapamycin for healthspan
Rapamycin was discovered in 1964 in soil from Easter Island and has long been used to prevent organ rejection after transplants. Research has since shown that it acts on the mTOR pathway, which controls the balance between cell growth and cell repair. At low, once-weekly doses, rapamycin appears to shift cells toward autophagy, the body’s natural process for clearing out damaged cell parts.
In animal studies, rapamycin is the most effective drug tested so far for extending lifespan, increasing median lifespan in mice by roughly 15–36%.
What human research shows so far:
• Cellular cleanup: a 2025 study in patients with chronic fatigue syndrome (ME/CFS) found improved autophagy markers and symptoms at 6 mg weekly
• Immune function in older adults: a 2014 trial found about a 20% better flu vaccine response with a related low-dose drug; a 2023 study reported lower rates of COVID-19 and long COVID among users
• Heart health: a 2025 trial found improved heart and blood vessel function in older men after eight weeks at 1 mg daily
• Reproductive health: a 2025 IVF study found better embryo quality and higher pregnancy rates at 1 mg daily
• Lean muscle: the year-long PEARL trial found about a 6% increase in lean body mass in women taking 10 mg weekly
What it doesn’t show. Rapamycin hasn’t been proven to extend human lifespan. The realistic goal is healthspan: staying healthier and more functional for longer.
Safety first
LDN and rapamycin are prescribed off-label for these uses. Before recommending either, Marianna reviews the evidence, the unknowns, and the alternatives with you. Treatment includes baseline labs and ongoing monitoring.